Discover premium-grade Epitalon, the synthetic tetrapeptide (Ala-Glu-Asp-Gly / AEDG) modeled on the pineal gland bioregulator epithalamin. Researchers and longevity scientists turn to Epitalon peptide for its documented ability to support telomerase activity, telomere maintenance, melatonin production, and age-related cellular research.
What Is Epitalon Peptide?
Epitalon (also known as Epithalon or Epithalone) is a short-chain synthetic peptide consisting of four amino acids: alanine, glutamic acid, aspartic acid, and glycine. Developed from research on the natural pineal extract epithalamin, this compact molecule (molecular weight ~390 Da) has been studied for over 25 years, primarily for its effects on cellular aging pathways.
Key research focus areas include:
• Telomerase activation and telomere length: In vitro studies (including independent 2025 work) show Epitalon can upregulate hTERT expression and increase telomerase activity in normal human fibroblasts and epithelial cells, helping maintain telomere length and extend replicative capacity beyond typical limits in cell culture.
• Melatonin and circadian support: Research indicates Epitalon helps normalize pineal melatonin secretion and circadian gene expression, with reported increases in nighttime melatonin production.
• Additional investigated effects: Antioxidant enzyme support, immune modulation markers, gene expression changes related to aging, and lifespan extension observations in rodent models.
Why Researchers Choose High-Purity Epitalon
• Supports studies on cellular senescence and the Hayflick limit
• Investigated for pineal and neuroendocrine research
• Short-cycle protocols common in published literature (typically 10–20 days)
• High solubility and stability when properly reconstituted
• Available in research-grade purity (≥98–99% by HPLC, with CoA)
Common research protocols (for laboratory use only):
Daily subcutaneous administration in the range of several hundred micrograms to low milligrams for 10–20 consecutive days, often repeated 1–2 times per year in animal or in-vitro models. Exact dosing depends on the experimental design.
Product Quality You Can Trust
Our Epitalon is lyophilized, third-party tested for identity, purity, and endotoxin levels. Store lyophilized powder frozen and protected from light; reconstitute with bacteriostatic water for research use. Suitable for in-vitro, cellular, and preclinical research applications.
Important: Epitalon is sold strictly for laboratory research purposes only. It is not intended for human or veterinary use, diagnosis, treatment, or prevention of any disease. Not FDA-approved for any therapeutic indication. Consult applicable regulations and institutional guidelines before use. Researchers should review the full body of literature, including limitations of primarily single-lab origin data and theoretical considerations around telomerase activity. For more information please refer to our comprehensive peptide library.
Order research-grade Epitalon peptide today and advance your work on telomeres, melatonin regulation, and cellular longevity mechanisms. High-purity AEDG available now with certificates of analysis.
Reviews
There are no reviews yet.