BioPharma CJC-1295 NO DAC 5mg

CJC-1295 No DAC (also known as Modified GRF 1-29 or Mod GRF 1-29) is a synthetic GHRH analog designed for laboratory research on growth hormone (GH) secretion and pituitary signaling. This short-acting peptide features four strategic amino acid substitutions that improve resistance to enzymatic degradation compared with native GHRH, while deliberately omitting the Drug Affinity Complex (DAC). The result is a half-life of approximately 30 minutes that produces a clean, pulsatile GH release pattern closely resembling natural physiology. 

Researchers choose CJC-1295 No DAC when they need controlled, transient stimulation of the GHRH receptor rather than prolonged elevation. It is widely studied alongside ghrelin-receptor agonists (such as Ipamorelin) for synergistic effects on GH pulse amplitude and frequency in preclinical models.

Key Research Advantages of CJC-1295 No DAC

•  Physiological pulsatile profile — Short half-life supports discrete GH pulses that return toward baseline, helping preserve receptor sensitivity in research settings.

•  Enhanced stability vs. native GHRH — Four substitutions (positions 2, 8, 15, and 27) reduce rapid DPP-IV cleavage.

•  Selective GHRH-receptor agonism — Acts on pituitary somatotrophs via cAMP-mediated pathways without the prolonged “bleed” associated with DAC-conjugated versions.

•  Ideal for combination studies — Frequently paired with selective growth hormone secretagogues to examine dual-receptor signaling.

•  Research-grade consistency — Supplied as lyophilized powder with batch-specific Certificates of Analysis (HPLC/LC-MS verified purity typically ≥98–99%).

Important: This product is intended strictly for laboratory research use only. It is not for human or veterinary consumption, diagnostic use, or therapeutic application. For more information please refer to our comprehensive peptide library.

Why Choose the No-DAC Form?

Unlike CJC-1295 with DAC (which binds serum albumin and extends half-life to several days), the No DAC version clears rapidly. This makes it the preferred tool for experiments requiring precise timing of GH pulses, comparison of short- vs. long-acting GHRH analogs, or protocols that aim to mimic endogenous secretory dynamics.

Order research-grade CJC-1295 No DAC today and advance your GH-axis and endocrine signaling studies with a well-characterized, short-acting GHRH analog.